RRC ID 11404
著者 Schatlowski N, Stahl Y, Hohenstatt ML, Goodrich J, Schubert D.
タイトル The CURLY LEAF interacting protein BLISTER controls expression of polycomb-group target genes and cellular differentiation of Arabidopsis thaliana.
ジャーナル Plant Cell
Abstract Polycomb-group (Pc-G) proteins are important regulators of many developmental processes in plants and animals and repress gene expression by imparting histone H3 lysine 27 trimethylation (H3K27me3). Here, we present the identification of the novel, plant-specific Arabidopsis thaliana protein BLISTER (BLI), which interacts with the Pc-G histone methyltransferase CURLY LEAF (CLF). We map the interaction of BLI with CLF to a predicted coiled-coil domain in BLI that shares similarity with STRUCTURAL MAINTENANCE OF CHROMOSOMES proteins. BLI colocalizes with CLF in the nucleus, shows an overlapping expression pattern with CLF throughout plant development that is strongest in dividing cells, and represses a subset of Pc-G target genes. Loss of BLI results in a pleiotropic developmental mutant phenotype, indicating that BLI prevents premature differentiation. Furthermore, bli mutants exhibit severe epidermal defects, including loss of cell adhesion, outgrowth of cells, and increased cotyledon cell size. As these phenotypes have not been observed in Pc-G mutants, we propose that BLI has functions related to Pc-G proteins but can also act independently in Arabidopsis development.
巻・号 22(7)
ページ 2291-305
公開日 2010-7-1
DOI 10.1105/tpc.109.073403
PII tpc.109.073403
PMID 20647345
PMC PMC2929108
MeSH Arabidopsis / cytology Arabidopsis / genetics* Arabidopsis Proteins / physiology* Cell Differentiation / physiology* Genes, Plant* Homeodomain Proteins / physiology* Mutation Polycomb-Group Proteins Repressor Proteins / genetics*
IF 9.618
引用数 29
WOS 分野 PLANT SCIENCES BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
シロイヌナズナ / 植物培養細胞・遺伝子 pda17320