論文 - 詳細
RRC ID | 36787 |
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著者 | Imamura K, Asai M, Sugamoto K, Matsumoto T, Yamasaki Y, Kamei I, Hattori T, Kishimoto M, Niisaka S, Kubo M, Nishiyama K, Yamasaki M. |
タイトル | Suppressing effect of cordycepin on the lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells. |
ジャーナル | Biosci Biotechnol Biochem |
Abstract |
In this study, we focused on the anti-inflammatory effect of cordycepin, 3'-deoxyadenosine. Cordycepin potently suppressed nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells in an adenosine receptor-independent manner. In addition, inhibitors for adenosine kinase and nucleoside transporter abrogated the action of cordycepin. Thus, we considered that intracellular metabolism cordycepin is important for the anti-inflammatory effect of cordycepin. |
巻・号 | 79(6) |
ページ | 1021-5 |
公開日 | 2015-1-1 |
DOI | 10.1080/09168451.2015.1008977 |
PMID | 25652735 |
MeSH | Animals Anti-Inflammatory Agents / metabolism Anti-Inflammatory Agents / pharmacology* Deoxyadenosines / metabolism Deoxyadenosines / pharmacology* Lipopolysaccharides / pharmacology* Macrophages / drug effects Macrophages / metabolism Mice Nitric Oxide / biosynthesis* RAW 264.7 Cells |
IF | 1.516 |
引用数 | 7 |
WOS 分野 | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY CHEMISTRY, APPLIED |
リソース情報 | |
ヒト・動物細胞 | RAW 264(RCB0535) |