RRC ID 48867
著者 Zhang S, Pan C, Lv X, Wu W, Chen H, Wu W, Wu H, Zhang L, Zhao Y.
タイトル Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis.
ジャーナル Sci Rep
Abstract Hox genes play a fundamental role in regulating animal development. However, less is known about their functions on homeostasis maintenance in adult stem cells. Here, we report that the repression of an important axial Hox gene, Abdominal-B (Abd-B), in cyst stem cells (CySCs) is essential for the homeostasis and cell identity maintenance in the adult Drosophila testis. Derepression of Abd-B in CySCs disrupts the proper self-renewal of both germline stem cells (GSCs) and CySCs, and leads to an excessive expansion of early stage somatic cells, which originate from both lineages. We further demonstrate that canonical Polycomb (Pc) and functional pathway of Polycomb group (PcG) proteins are responsible for maintaining the germline cell identity non-autonomously via repressing Abd-B in CySCs in the adult Drosophila testis.
巻・号 7(1)
ページ 5101
公開日 2017-7-11
DOI 10.1038/s41598-017-05359-0
PII 10.1038/s41598-017-05359-0
PMID 28698559
PMC PMC5506049
MeSH Animals Cell Lineage Cells, Cultured Drosophila / cytology* Drosophila / genetics Drosophila / metabolism Drosophila Proteins / genetics* Drosophila Proteins / metabolism* Histones / metabolism Homeodomain Proteins / genetics* Homeodomain Proteins / metabolism* Male Polycomb Repressive Complex 1 / genetics Polycomb Repressive Complex 1 / metabolism* Polycomb-Group Proteins / metabolism Spermatozoa / cytology Spermatozoa / metabolism Stem Cells / cytology Stem Cells / metabolism Testis / cytology* Testis / metabolism
IF 3.998
引用数 2
WOS 分野 CELL BIOLOGY
リソース情報
ショウジョウバエ 32443R-4 32443R-1 5595R-1