RRC ID 52632
著者 Monzen S, Chiba M, Ueno T, Morino Y, Terada K, Yamaya H, Hosokawa Y.
タイトル A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression.
ジャーナル Oncol Lett
Abstract In the present study, the cell viability and cluster of differentiation (CD)38 mRNA expression were evaluated in radioresistant (Res)-HL60 acute promyelocytic leukemia (APL) cells. Cell viability in Res-HL60 cells was higher compared with wild-type HL60 cells, but did not differ between high and mid/low CD38 antigen expression groups in Res-HL60 cells. A higher expression of CD38 mRNA in Res-HL60 cells was observed, particularly in the CD38high cell subpopulation. Furthermore, the expression of CD38 mRNA was upregulated following exposure to X-irradiation. In contrast, the characteristic expression of CD45 and CCAAT/enhancer-binding protein α mRNA were not altered. These results suggest that the accumulation of CD38 protein in radioresistant APL cells, resulting from the constant expression of CD38 mRNA induced by X-irradiation, is a characteristic response of the radioresistant-surviving fraction; however, the accumulation of CD38 did not influence the extent of radioresistant behavior.
巻・号 15(5)
ページ 6709-6714
公開日 2018-5-1
DOI 10.3892/ol.2018.8099
PII OL-0-0-8099
PMID 29616132
PMC PMC5876438
IF 2.311
引用数 0
リソース情報
ヒト・動物細胞 HL60(RCB0041)