論文 - 詳細
| RRC ID | 34253 |
|---|---|
| 著者 | Chohnan S, Murase M, Kurikawa K, Higashi K, Ogata Y. |
| タイトル | Antimicrobial activity of pantothenol against staphylococci possessing a prokaryotic type II pantothenate kinase. |
| ジャーナル | Microbes Environ |
| Abstract |
Pantothenol is a provitamin of pantothenic acid (vitamin B5) that is widely used in healthcare and cosmetic products. This analog of pantothenate has been shown to markedly inhibit the phosphorylation activity of the prokaryotic type II pantothenate kinase of Staphylococcus aureus, which catalyzes the first step of the coenzyme A biosynthetic pathway. Since type II enzymes are found exclusively in staphylococci, pantothenol suppresses the growth of S. aureus, S. epidermidis, and S. saprophyticus, which inhabit the skin of humans. Therefore, the addition of this provitamin to ointment and skincare products may be highly effective in preventing infections by opportunistic pathogens. |
| 巻・号 | 29(2) |
| ページ | 224-6 |
| 公開日 | 2014-1-1 |
| DOI | 10.1264/jsme2.me13178 |
| PII | DN/JST.JSTAGE/jsme2/ME13178 |
| PMID | 24759689 |
| PMC | PMC4103530 |
| MeSH | Amino Acid Sequence Anti-Infective Agents / pharmacology* Bacterial Proteins / antagonists & inhibitors Biosynthetic Pathways / drug effects Coenzyme A / biosynthesis Escherichia coli K12 / drug effects Escherichia coli K12 / enzymology Escherichia coli K12 / growth & development Humans Microbial Sensitivity Tests Pantothenic Acid / analogs & derivatives* Pantothenic Acid / chemistry Pantothenic Acid / pharmacology Phosphorylation / drug effects Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors* Pseudomonas putida / drug effects Pseudomonas putida / enzymology Pseudomonas putida / growth & development Staphylococcal Infections / drug therapy* Staphylococcal Infections / microbiology Staphylococcus / drug effects* Staphylococcus / enzymology Staphylococcus / growth & development |
| IF | 2.575 |
| 引用数 | 1 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY |
| リソース情報 | |
| 一般微生物 | JCM 20089 |