RRC ID 51560
著者 Lee SH, Omi S, Thakur N, Taffoni C, Belougne J, Engelmann I, Ewbank JJ, Pujol N.
タイトル Modulatory upregulation of an insulin peptide gene by different pathogens in C. elegans.
ジャーナル Virulence
Abstract When an animal is infected, its innate immune response needs to be tightly regulated across tissues and coordinated with other aspects of organismal physiology. Previous studies with Caenorhabditis elegans have demonstrated that insulin-like peptide genes are differentially expressed in response to different pathogens. They represent prime candidates for conveying signals between tissues upon infection. Here, we focused on one such gene, ins-11 and its potential role in mediating cross-tissue regulation of innate immune genes. While diverse bacterial intestinal infections can trigger the up-regulation of ins-11 in the intestine, we show that epidermal infection with the fungus Drechmeria coniospora triggers an upregulation of ins-11 in the epidermis. Using the Shigella virulence factor OpsF, a MAP kinase inhibitor, we found that in both cases, ins-11 expression is controlled cell autonomously by p38 MAPK, but via distinct transcription factors, STA-2/STAT in the epidermis and HLH-30/TFEB in the intestine. We established that ins-11, and the insulin signaling pathway more generally, are not involved in the regulation of antimicrobial peptide gene expression in the epidermis. The up-regulation of ins-11 in the epidermis does, however, affect intestinal gene expression in a complex manner, and has a deleterious effect on longevity. These results support a model in which insulin signaling, via ins-11, contributes to the coordination of the organismal response to infection, influencing the allocation of resources in an infected animal.
巻・号 9(1)
ページ 648-658
公開日 2018-12-31
DOI 10.1080/21505594.2018.1433969
PMID 29405821
PMC PMC5955453
MeSH Animals Bacterial Proteins / metabolism Caenorhabditis elegans / microbiology* Caenorhabditis elegans Proteins / biosynthesis* Epidermis / microbiology Gene Expression Regulation* Hypocreales / growth & development* Intestines / microbiology Peptide Hormones / biosynthesis* Transcription Factors / metabolism Virulence Factors / metabolism p38 Mitogen-Activated Protein Kinases / metabolism
IF 5.542
引用数 5
リソース情報
線虫 tm1053 tm1978