RRC ID 51331
著者 Delaney CE, Chen AT, Graniel JV, Dumas KJ, Hu PJ.
タイトル A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity.
ジャーナル Development
Abstract Animals change developmental fates in response to external cues. In the nematode Caenorhabditis elegans, unfavorable environmental conditions induce a state of diapause known as dauer by inhibiting the conserved DAF-2 insulin-like signaling (ILS) pathway through incompletely understood mechanisms. We have previously established a role for the C. elegans dosage compensation protein DPY-21 in the control of dauer arrest and DAF-2 ILS. Here, we show that the histone H4 lysine 20 methyltransferase SET-4, which also influences dosage compensation, promotes dauer arrest in part by repressing the X-linked ins-9 gene, which encodes a new agonist insulin-like peptide (ILP) expressed specifically in the paired ASI sensory neurons that are required for dauer bypass. ins-9 repression in dauer-constitutive mutants requires DPY-21, SET-4 and the FoxO transcription factor DAF-16, which is the main target of DAF-2 ILS. By contrast, autosomal genes encoding major agonist ILPs that promote reproductive development are not repressed by DPY-21, SET-4 or DAF-16/FoxO. Our results implicate SET-4 as a sensory rheostat that reinforces developmental fates in response to environmental cues by modulating autocrine and paracrine DAF-2 ILS.
巻・号 144(7)
ページ 1273-1282
公開日 2017-4-1
DOI 10.1242/dev.145722
PII dev.145722
PMID 28209779
PMC PMC5399626
MeSH Animals Caenorhabditis elegans / enzymology* Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development* Caenorhabditis elegans Proteins / metabolism* Environment* Female Gene Expression Profiling Gene Expression Regulation, Developmental Genes, X-Linked Histone-Lysine N-Methyltransferase / metabolism* Histones / metabolism* Larva / metabolism Lysine / metabolism* Male Models, Biological Mutation / genetics Neuronal Plasticity* Sensory Receptor Cells / physiology* Sex Characteristics Transcriptome / genetics
IF 5.611
引用数 8
リソース情報
線虫 tm1907 tm3188 tm3618