RRC ID 48506
著者 Cho O, Sugita T.
タイトル Low DNA Sequence Diversity of the Intergenic Spacer 1 Region in the Human Skin Commensal Fungi Malassezia sympodialis and M. dermatis Isolated from Patients with Malassezia-Associated Skin Diseases and Healthy Subjects.
ジャーナル Mycopathologia
Abstract As DNA sequences of the intergenic spacer (IGS) region in the rRNA gene show remarkable intraspecies diversity compared with the small subunit, large subunit, and internal transcribed spacer region, the IGS region has been used as an epidemiological tool in studies on Malassezia globosa and M. restricta, which are responsible for the exacerbation of atopic dermatitis (AD) and seborrheic dermatitis (SD). However, the IGS regions of M. sympodialis and M. dermatis obtained from the skin of patients with AD and SD, as well as healthy subjects, lacked sequence diversity. Of the 105 M. sympodialis strains and the 40 M. dermatis strains, the sequences of 103 (98.1 %) and 39 (97.5 %), respectively, were identical. Thus, given the lack of intraspecies diversity in the IGS regions of M. sympodialis and M. dermatis, studies of the diversity of these species should be performed using appropriate genes and not the IGS.
巻・号 181(11-12)
ページ 839-842
公開日 2016-12-1
DOI 10.1007/s11046-016-0034-3
PII 10.1007/s11046-016-0034-3
PMID 27371104
MeSH Cluster Analysis DNA, Fungal / chemistry DNA, Fungal / genetics DNA, Ribosomal Spacer / chemistry DNA, Ribosomal Spacer / genetics* Dermatomycoses / microbiology* Genetic Variation* Healthy Volunteers* Humans Malassezia / classification Malassezia / genetics* Malassezia / isolation & purification* Phylogeny Sequence Analysis, DNA
IF 2.452
引用数 0
WOS 分野 MYCOLOGY
リソース情報
一般微生物 JCM 11348