RRC ID |
33675
|
著者 |
Wada H, Ghysen A, Asakawa K, Abe G, Ishitani T, Kawakami K.
|
タイトル |
Wnt/Dkk negative feedback regulates sensory organ size in zebrafish.
|
ジャーナル |
Curr Biol
|
Abstract |
Correct organ size must involve a balance between promotion and inhibition of cell proliferation. A mathematical model has been proposed in which an organ is assumed to produce its own growth activator as well as a growth inhibitor [1], but there is as yet no molecular evidence to support this model [2]. The mechanosensory organs of the fish lateral line system (neuromasts) are composed of a core of sensory hair cells surrounded by nonsensory support cells. Sensory cells are constantly replaced and are regenerated from surrounding nonsensory cells [3], while each organ retains the same size throughout life. Moreover, neuromasts also bud off new neuromasts, which stop growing when they reach the same size [4, 5]. Here, we show that the size of neuromasts is controlled by a balance between growth-promoting Wnt signaling activity in proliferation-competent cells and Wnt-inhibiting Dkk activity produced by differentiated sensory cells. This negative feedback loop from Dkk (secreted by differentiated cells) on Wnt-dependent cell proliferation (in surrounding cells) also acts during regeneration to achieve size constancy. This study establishes Wnt/Dkk as a novel mechanism to determine the final size of an organ.
|
巻・号 |
23(16)
|
ページ |
1559-65
|
公開日 |
2013-8-19
|
DOI |
10.1016/j.cub.2013.06.035
|
PII |
S0960-9822(13)00760-4
|
PMID |
23891113
|
MeSH |
Animals
Animals, Genetically Modified / genetics
Animals, Genetically Modified / growth & development
Animals, Genetically Modified / physiology
Cell Differentiation
Cell Proliferation
Feedback
Gene Expression Regulation, Developmental
Intercellular Signaling Peptides and Proteins / genetics*
Intercellular Signaling Peptides and Proteins / metabolism
Lateral Line System / anatomy & histology
Lateral Line System / growth & development*
Organ Size
Polymerase Chain Reaction
Regeneration
Wnt Signaling Pathway*
Zebrafish / genetics
Zebrafish / growth & development
Zebrafish / physiology*
Zebrafish Proteins / genetics*
Zebrafish Proteins / metabolism
|
IF |
9.601
|
引用数 |
40
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
リソース情報 |
ゼブラフィッシュ |
Tg(6xTcf/LefBS-miniP:d2EGFP)isi01 |