RRC ID |
32383
|
著者 |
Nelson MD, Lee KH, Churgin MA, Hill AJ, Van Buskirk C, Fang-Yen C, Raizen DM.
|
タイトル |
FMRFamide-like FLP-13 neuropeptides promote quiescence following heat stress in Caenorhabditis elegans.
|
ジャーナル |
Curr Biol
|
Abstract |
Among the most important decisions an animal makes is whether to engage in active movement and feeding behavior or to become quiescent. The molecular signaling mechanisms underlying this decision remain largely unknown. The nematode Caenorhabditis elegans displays sleep-like quiescence following exposures that result in cellular stress. The neurosecretory ALA neuron is required for this stress-induced recovery quiescence, but the mechanisms by which ALA induces quiescence have been unknown. We report here that quiescence induced by heat stress requires ALA depolarization and release of FMRFamide-like neuropeptides encoded by the flp-13 gene. Optogenetic activation of ALA reduces feeding and locomotion in a FLP-13-dependent manner. Overexpression of flp-13 is sufficient to induce quiescent behavior during normally active periods. We have here identified a major biological role for FMRFamide-like neuropeptides in nematodes, and we suggest that they may function in a similar capacity in other organisms.
|
巻・号 |
24(20)
|
ページ |
2406-10
|
公開日 |
2014-10-20
|
DOI |
10.1016/j.cub.2014.08.037
|
PII |
S0960-9822(14)01050-1
|
PMID |
25264253
|
PMC |
PMC4254296
|
MeSH |
Animals
Animals, Genetically Modified
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans / physiology
Caenorhabditis elegans Proteins / metabolism*
Caenorhabditis elegans Proteins / physiology
Chloride Channels / genetics
Chloride Channels / metabolism
Drosophila Proteins / genetics
Drosophila Proteins / metabolism
FMRFamide / analogs & derivatives*
FMRFamide / genetics
FMRFamide / metabolism
Feeding Behavior
Gene Expression Regulation
Hot Temperature / adverse effects*
Locomotion / physiology
Stress, Physiological / physiology*
|
IF |
9.601
|
引用数 |
56
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
リソース情報 |
線虫 |
tm2427 |