RRC ID 15305
著者 Mead TJ, Yutzey KE.
タイトル Notch pathway regulation of neural crest cell development in vivo.
ジャーナル Dev Dyn
Abstract BACKGROUND:The function of Notch signaling in murine neural crest-derived cell lineages in vivo was examined.
RESULTS:Conditional gain (Wnt1Cre;Rosa(Notch)) or loss (Wnt1Cre;RBP-J(f/f)) of Notch signaling in neural crest cells (NCCs) in vivo results in craniofacial, cardiac, and trunk abnormalities. Severe craniofacial malformations are apparent in Wnt1Cre;Rosa(Notch) embryos, while less severe skull abnormalities are evident in Wnt1Cre;RBP-J(f/f) mice. Deficient cardiac neural crest migration, resulting in cardiac outflow tract malformations, occurs with increased or decreased Notch signaling in NCCs. Smooth muscle cell differentiation also is impaired in pharyngeal NCC derivatives in both Wnt1Cre;Rosa(Notch) and Wnt1Cre;RBP-J(f/f) embryos. Neurogenesis is absent and gliogenesis is increased in the dorsal root ganglia of Wnt1Cre;Rosa(Notch) embryos, while neurogenesis is increased and gliogenesis is decreased in Wnt1Cre;RBP-J(f/f) embryos.
CONCLUSIONS:Together, these studies demonstrate essential cell-autonomous roles for appropriate levels of Notch signaling during NCC migration, proliferation, and differentiation with critical implications in craniofacial, cardiac, and neurogenic development and disease.
巻・号 241(2)
ページ 376-89
公開日 2012-2-1
DOI 10.1002/dvdy.23717
PMID 22275227
PMC PMC3266628
MeSH Animals Branchial Region / blood supply Branchial Region / embryology Cell Differentiation* Cell Lineage Cell Movement Cell Proliferation Heart Defects, Congenital / genetics Mice Mice, Mutant Strains Myocytes, Smooth Muscle / physiology Neural Crest / cytology* Neural Crest / embryology* Receptors, Notch / genetics Receptors, Notch / metabolism* Signal Transduction Wnt1 Protein / metabolism
IF 3.275
引用数 34
WOS 分野 ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY
リソース情報
実験動物マウス RBRC01071