RRC ID 36399
著者 Ito K, Morioka M, Kimura S, Tasaki M, Inohaya K, Kudo A.
タイトル Differential reparative phenotypes between zebrafish and medaka after cardiac injury.
ジャーナル Dev Dyn
Abstract BACKGROUND:Zebrafish have the ability for heart regeneration. However, another teleost animal model, the medaka, had not yet been investigated for this capacity.
RESULTS:Compared with zebrafish, the medaka heart responded differently to an injury: An excessive fibrotic response occurred in the medaka heart, and existing cardiomyocytes or cardiac progenitor cells remained dormant, resulting in no numerical difference between the uncut and injured heart with respect to the number of EdU-incorporated cardiomyocytes. The results obtained from the analysis of the medaka raldh2-GFP transgenic line showed a lack of raldh2 expression in the endocardium. Regarding periostin expression, the localization of medaka periostin-b, a marker of fibrillogenesis, in the medaka heart remained at the wound site at 30 dpa; whereas zebrafish periostin-b was no longer localized at the wound but was detected in the epicardium at that time.
CONCLUSIONS:Compared with zebrafish heart regeneration, the medaka heart phenotypes suggest the possibility that the medaka could hardly regenerate its heart tissue or that these phenotypes for heart regeneration showed a delay.
巻・号 243(9)
ページ 1106-15
公開日 2014-9-1
DOI 10.1002/dvdy.24154
PMID 24947076
MeSH Animals Animals, Genetically Modified Cell Proliferation Heart / physiology* Heart Injuries / physiopathology* Myocardium / metabolism Oryzias Phenotype Regeneration / physiology* Zebrafish
IF 3.275
引用数 51
WOS 分野 ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY
リソース情報
メダカ OK-Cab (MT830) fosmid clone (GOLWF no 683_j24) Kaga Database