RRC ID 46603
著者 Harrington AJ, Hamamichi S, Caldwell GA, Caldwell KA.
タイトル C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease.
ジャーナル Dev Dyn
Abstract Parkinson's disease (PD) is an age-related movement disorder resulting, in part, from selective loss of dopaminergic neurons. Both invertebrate and mammalian models have been developed to study the cellular mechanisms altered during disease progression; nevertheless there are limitations within each model. Mammalian models remain invaluable in studying PD, but are expensive and time consuming. Here, we review genetic and environmental factors associated with PD, and describe how the nematode roundworm, Caenorhabditis elegans, has been used as a model organism for studying various aspects of this neurodegenerative disease. Both genetic and chemical screens have been conducted in C. elegans to identify molecular pathways, proteins, and small molecules that can impact PD pathology. Lastly, we highlight future areas of investigation, in the context of emerging fields in biology, where the nematode can be exploited to provide mechanistic insights and potential strategies to accelerate the path toward possible therapeutic intervention for PD.
巻・号 239(5)
ページ 1282-95
公開日 2010-5-1
DOI 10.1002/dvdy.22231
PMID 20108318
MeSH Animals Caenorhabditis elegans Disease Models, Animal Metabolic Networks and Pathways Parkinson Disease / genetics Parkinson Disease / metabolism*
IF 3.275
引用数 79
WOS 分野 ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY
リソース情報
線虫 tm1898 tm1779