RRC ID 52588
著者 Wei L, Yan N, Sun L, Bao C, Li D.
タイトル Interplay between the NF‑κB and hedgehog signaling pathways predicts prognosis in esophageal squamous cell carcinoma following neoadjuvant chemoradiotherapy.
ジャーナル Int J Mol Med
Abstract Tumor recurrence and metastasis in esophageal squamous cell carcinoma (ESCC) are primary causes of patient mortality. The nuclear factor (NF)‑κB signaling pathway and hedgehog signaling pathway were previously reported to contribute to cell growth and metastasis in ESCC. The present study therefore investigated the roles of the NF‑κB and hedgehog pathways in ESCC tumors following neoadjuvant chemoradiotherapy (NCRT). By immunohistochemistry staining, it was observed that NF‑κB and glioma‑associated oncogene homolog 1 (Gli1), key components of the NF‑κB and hedgehog pathways, respectively, were decreased following NCRT, which was further confirmed by western blotting and reverse transcription‑quantitative polymerase chain reaction analysis. In addition, survival analysis suggested that high expression levels of either NF‑κB or Gli1 were associated with poor overall survival (OS) of patients. In the esophageal cell line TE‑8, NF‑κB and Gli1 formed a positive feedback loop, and inhibition of either NF‑κB or Gli1 may inhibit cell migration, invasion and proliferation. The results of the present study demonstrated that activation of the NF‑κB and hedgehog signaling pathways limited the OS of patients with ESCC following NCRT, and may therefore be suitable targets for ESCC treatment.
巻・号 41(5)
ページ 2961-2967
公開日 2018-5-1
DOI 10.3892/ijmm.2018.3447
PMID 29393402
MeSH Adult Aged Carcinoma, Squamous Cell / diagnosis* Carcinoma, Squamous Cell / metabolism Carcinoma, Squamous Cell / pathology Carcinoma, Squamous Cell / therapy* Cell Line, Tumor Chemoradiotherapy / methods Esophageal Neoplasms / diagnosis* Esophageal Neoplasms / metabolism Esophageal Neoplasms / pathology Esophageal Neoplasms / therapy* Esophageal Squamous Cell Carcinoma Female Hedgehog Proteins / metabolism* Humans Male Middle Aged NF-kappa B / metabolism* Neoadjuvant Therapy / methods Prognosis Signal Transduction / drug effects Signal Transduction / radiation effects
IF 3.098
引用数 2
リソース情報
ヒト・動物細胞 TE-8(RCB2098)