| RRC ID |
27197
|
| 著者 |
Tang H, Serada S, Kawabata A, Ota M, Hayashi E, Naka T, Yamanishi K, Mori Y.
|
| タイトル |
CD134 is a cellular receptor specific for human herpesvirus-6B entry.
|
| ジャーナル |
Proc Natl Acad Sci U S A
|
| Abstract |
Human herpesvirus-6B (HHV-6B) is a T lymphotropic β-herpesvirus that is clearly distinct from human herpesvirus-6A (HHV-6A) according to molecular biological features. The International Committee on Taxonomy of Viruses recently classified HHV-6B as a separate species. The primary HHV-6B infection causes exanthem subitum and is sometimes associated with severe encephalopathy. More than 90% of the general population is infected with HHV-6B during childhood, and the virus remains throughout life as a latent infection. HHV-6B reactivation causes encephalitis in immunosuppressed patients. The cellular receptor for HHV-6A entry was identified as human CD46, but the receptor for HHV-6B has not been clear. Here we found that CD134, a member of the TNF receptor superfamily, functions as a specific entry receptor for HHV-6B. A T-cell line that is normally nonpermissive for HHV-6B infection became highly susceptible to infection when CD134 was overexpressed. CD134 was down-regulated in HHV-6B-infected T cells. Soluble CD134 interacted with the HHV-6B glycoprotein complex that serves as a viral ligand for cellular receptor, which inhibited HHV-6B but not HHV-6A infection in target cells. The identification of CD134 as an HHV-6B specific entry receptor provides important insight into understanding HHV-6B entry and its pathogenesis.
|
| 巻・号 |
110(22)
|
| ページ |
9096-9
|
| 公開日 |
2013-5-28
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| DOI |
10.1073/pnas.1305187110
|
| PII |
1305187110
|
| PMID |
23674671
|
| PMC |
PMC3670305
|
| MeSH |
Flow Cytometry
HEK293 Cells
Herpesvirus 6, Human / metabolism
Herpesvirus 6, Human / physiology*
Humans
Plasmids / genetics
Receptors, OX40 / metabolism*
T-Lymphocytes / metabolism
T-Lymphocytes / virology
Viral Fusion Proteins / metabolism*
Virus Internalization*
|
| IF |
9.412
|
|
WOS 分野
|
VIROLOGY
|
| リソース情報 |
| 研究用ヒト臍帯血幹細胞 |
|
