RRC ID 45539
著者 Chien SC, Gurling M, Kim C, Craft T, Forrester W, Garriga G.
タイトル Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1.
ジャーナル Dev Biol
Abstract Wnts are a conserved family of secreted glycoproteins that regulate various developmental processes in metazoans. Three of the five Caenorhabditis elegans Wnts, CWN-1, CWN-2 and EGL-20, and the sole Wnt receptor of the Ror kinase family, CAM-1, are known to regulate the anterior polarization of the mechanosensory neuron ALM. Here we show that CAM-1 and the Frizzled receptor MOM-5 act in parallel pathways to control ALM polarity. We also show that CAM-1 has two functions in this process: an autonomous signaling function that promotes anterior polarization and a nonautonomous Wnt-antagonistic function that inhibits anterior polarization. These antagonistic activities can account for the weak ALM phenotypes displayed by cam-1 mutants. Our observations suggest that CAM-1 could function as a Wnt receptor in many developmental processes, but the analysis of cam-1 mutants may fail to reveal CAM-1's role as a receptor in these processes because of its Wnt-antagonistic activity. In this model, loss of CAM-1 results in increased levels of Wnts that act through other Wnt receptors, masking CAM-1's autonomous role as a Wnt receptor.
巻・号 404(1)
ページ 55-65
公開日 2015-8-1
DOI 10.1016/j.ydbio.2015.04.015
PII S0012-1606(15)00217-1
PMID 25917219
PMC PMC4556527
MeSH Animals Animals, Genetically Modified Caenorhabditis elegans / cytology* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / metabolism* Cell Polarity Membrane Proteins / metabolism* Neurons / cytology* Neurons / metabolism Receptor Tyrosine Kinase-like Orphan Receptors / metabolism* Wnt Signaling Pathway*
IF 2.896
引用数 9
WOS 分野 DEVELOPMENTAL BIOLOGY
リソース情報
線虫 tm1422