RRC ID 36657
著者 Ota M, Serada S, Naka T, Mori Y.
タイトル MHC class I molecules are incorporated into human herpesvirus-6 viral particles and released into the extracellular environment.
ジャーナル Microbiol Immunol
Abstract Human herpesvirus-6 (HHV-6), which belongs to the betaherpesvirus subfamily, mainly replicates in T lymphocytes. Here, we show that MHC class I molecules are incorporated into HHV-6 viral particles and released into the extracellular environment. In addition, HHV-6A/B-infected T cells showed reduced surface and intracellular expression of MHC class I molecules. The cellular machinery responsible for molecular transport appears to be modified upon HHV-6 infection, causing MHC class I molecules to be transported to virion assembly sites.
巻・号 58(2)
ページ 119-25
公開日 2014-2-1
DOI 10.1111/1348-0421.12121
PMID 24330265
MeSH Cell Line Down-Regulation Exosomes / metabolism Extracellular Space / metabolism Herpesvirus 6, Human / immunology Herpesvirus 6, Human / physiology* Histocompatibility Antigens Class I / metabolism* Humans Models, Biological Protein Transport Subcellular Fractions / metabolism Virion* / immunology
IF 1.566
引用数 17
WOS 分野 IMMUNOLOGY MICROBIOLOGY
リソース情報
研究用ヒト臍帯血幹細胞 研究用ヒト臍帯血幹細胞