論文 - 詳細
RRC ID | 36657 |
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著者 | Ota M, Serada S, Naka T, Mori Y. |
タイトル | MHC class I molecules are incorporated into human herpesvirus-6 viral particles and released into the extracellular environment. |
ジャーナル | Microbiol Immunol |
Abstract |
Human herpesvirus-6 (HHV-6), which belongs to the betaherpesvirus subfamily, mainly replicates in T lymphocytes. Here, we show that MHC class I molecules are incorporated into HHV-6 viral particles and released into the extracellular environment. In addition, HHV-6A/B-infected T cells showed reduced surface and intracellular expression of MHC class I molecules. The cellular machinery responsible for molecular transport appears to be modified upon HHV-6 infection, causing MHC class I molecules to be transported to virion assembly sites. |
巻・号 | 58(2) |
ページ | 119-25 |
公開日 | 2014-2-1 |
DOI | 10.1111/1348-0421.12121 |
PMID | 24330265 |
MeSH | Cell Line Down-Regulation Exosomes / metabolism Extracellular Space / metabolism Herpesvirus 6, Human / immunology Herpesvirus 6, Human / physiology* Histocompatibility Antigens Class I / metabolism* Humans Models, Biological Protein Transport Subcellular Fractions / metabolism Virion* / immunology |
IF | 1.566 |
引用数 | 17 |
WOS 分野 | IMMUNOLOGY MICROBIOLOGY |
リソース情報 | |
研究用ヒト臍帯血幹細胞 | 研究用ヒト臍帯血幹細胞 |