RRC ID 45841
著者 Rojo Romanos T, Petersen JG, Riveiro AR, Pocock R.
タイトル A novel role for the zinc-finger transcription factor EGL-46 in the differentiation of gas-sensing neurons in Caenorhabditis elegans.
ジャーナル Genetics
Abstract Oxygen (O2) and carbon dioxide (CO2) provoke distinct olfactory behaviors via specialized sensory neurons across metazoa. In the nematode C. elegans, the BAG sensory neurons are specialized to sense changes in both O2 and CO2 levels in the environment. The precise functionality of these neurons is specified by the coexpression of a membrane-bound receptor-type guanylyl cyclase GCY-9 that is required for responses to CO2 upshifts and the soluble guanylyl cyclases GCY-31 and GCY-33 that mediate responses to downshifts in O2. Expression of these gas-sensing molecules in the BAG neurons is partially, although not completely, controlled by ETS-5, an ETS-domain-containing transcription factor, and EGL-13, a Sox transcription factor. We report here the identification of EGL-46, a zinc-finger transcription factor, which regulates BAG gas-sensing fate in partially parallel pathways to ETS-5 and EGL-13. Thereby, three conserved transcription factors collaborate to ensure neuron type-specific identity features of the BAG gas-sensing neurons.
巻・号 199(1)
ページ 157-63
公開日 2015-1-1
DOI 10.1534/genetics.114.172049
PII genetics.114.172049
PMID 25395666
PMC PMC4286680
MeSH Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carbon Dioxide / pharmacology Chemoreceptor Cells / drug effects Chemoreceptor Cells / metabolism* Guanylate Cyclase / genetics Guanylate Cyclase / metabolism Neurogenesis* Oxygen / pharmacology Transcription Factors / genetics Transcription Factors / metabolism*
IF 4.015
引用数 7
リソース情報
線虫 tm1734