RRC ID |
18703
|
著者 |
Ohguchi K, Nakajima C, Oyama M, Iinuma M, Itoh T, Akao Y, Nozawa Y, Ito M.
|
タイトル |
Inhibitory effects of flavonoid glycosides isolated from the peel of Japanese persimmon (Diospyros kaki 'Fuyu') on melanin biosynthesis.
|
ジャーナル |
Biol Pharm Bull
|
Abstract |
We found that the acetone extract of the peel of Japanese persimmon (Diospyros kaki 'Fuyu') inhibits melanin biosynthesis in mouse B16 melanoma cells. The activity-guided purification of the extract resulted in isolation of two active compounds, which have been identified as flavonoid glycosides, isoquercitrin (quercetin-3-O-glucoside) and hyperin (quercetin-3-O-galactoside) by spectral analysis. Isoquercitrin and hyperin strongly inhibited the production of melanin (IC(50): 21.7 and 18.2 microM, respectively). The inhibitory effects were found to be mediated by suppression of tyrosinase expression.
|
巻・号 |
33(1)
|
ページ |
122-4
|
公開日 |
2010-1-1
|
DOI |
10.1248/bpb.33.122
|
PII |
JST.JSTAGE/bpb/33.122
|
PMID |
20045948
|
MeSH |
Animals
Cell Line, Tumor
Diospyros / chemistry*
Flavonoids / isolation & purification
Flavonoids / pharmacology*
Fruit
Glucosides
Melanins / biosynthesis*
Mice
Monophenol Monooxygenase / metabolism*
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Quercetin / analogs & derivatives
|
IF |
1.863
|
引用数 |
23
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
|
リソース情報 |
ヒト・動物細胞 |
B16 melanoma 4A5(RCB0557) |