RRC ID 41747
著者 Meselhy MR.
タイトル Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents.
ジャーナル Phytochemistry
Abstract Three new (1-3) and five known compounds (4-8) were isolated from the oleogum resin of Commiphora wightii (Arnott.) Bhanol. Their structures were elucidated by spectroscopic and chemical methods. The MeOH extract and the EtOAc-sol. fraction were found to demonstrate significant inhibition of NO formation in lipopolysaccharide (LPS)-activated murine macrophages J774.1 in vitro (IC(50) values of 16.4 and 12.8 microg/ml, respectively). When compared with curcumin (IC(50) value of 12.3 microM), Z- and E-Guggulsterones (4 and 5, respectively) were the most potent inhibitors of NO production (IC(50) values of 1.1 and 3.3 microM, respectively), followed by myrrhanol A (7) and myrrhanone A (8) (IC(50) values of 21.1 and 42.3 microM, respectively). Guggulsterone-M (1) and its didehydro derivative (2) were weak inhibitors, while guggulsterols I (6) and Y (3) were inactive (IC(50) >500 microM).
巻・号 62(2)
ページ 213-8
公開日 2003-1-1
DOI 10.1016/s0031-9422(02)00388-6
PII S0031942202003886
PMID 12482459
MeSH Animals Cells, Cultured Commiphora / chemistry* Inhibitory Concentration 50 Lipopolysaccharides / pharmacology* Macrophages / drug effects Macrophages / metabolism Magnetic Resonance Spectroscopy Mice Molecular Structure Nitric Oxide / metabolism* Resins, Plant / chemistry* Resins, Plant / pharmacology*
IF 3.044
引用数 55
WOS 分野 PLANT SCIENCES BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞 J774.1(RCB0434)