RRC ID 33675
著者 Wada H, Ghysen A, Asakawa K, Abe G, Ishitani T, Kawakami K.
タイトル Wnt/Dkk negative feedback regulates sensory organ size in zebrafish.
ジャーナル Curr Biol
Abstract Correct organ size must involve a balance between promotion and inhibition of cell proliferation. A mathematical model has been proposed in which an organ is assumed to produce its own growth activator as well as a growth inhibitor [1], but there is as yet no molecular evidence to support this model [2]. The mechanosensory organs of the fish lateral line system (neuromasts) are composed of a core of sensory hair cells surrounded by nonsensory support cells. Sensory cells are constantly replaced and are regenerated from surrounding nonsensory cells [3], while each organ retains the same size throughout life. Moreover, neuromasts also bud off new neuromasts, which stop growing when they reach the same size [4, 5]. Here, we show that the size of neuromasts is controlled by a balance between growth-promoting Wnt signaling activity in proliferation-competent cells and Wnt-inhibiting Dkk activity produced by differentiated sensory cells. This negative feedback loop from Dkk (secreted by differentiated cells) on Wnt-dependent cell proliferation (in surrounding cells) also acts during regeneration to achieve size constancy. This study establishes Wnt/Dkk as a novel mechanism to determine the final size of an organ.
巻・号 23(16)
ページ 1559-65
公開日 2013-8-19
DOI 10.1016/j.cub.2013.06.035
PII S0960-9822(13)00760-4
PMID 23891113
MeSH Animals Animals, Genetically Modified / genetics Animals, Genetically Modified / growth & development Animals, Genetically Modified / physiology Cell Differentiation Cell Proliferation Feedback Gene Expression Regulation, Developmental Intercellular Signaling Peptides and Proteins / genetics* Intercellular Signaling Peptides and Proteins / metabolism Lateral Line System / anatomy & histology Lateral Line System / growth & development* Organ Size Polymerase Chain Reaction Regeneration Wnt Signaling Pathway* Zebrafish / genetics Zebrafish / growth & development Zebrafish / physiology* Zebrafish Proteins / genetics* Zebrafish Proteins / metabolism
IF 9.601
引用数 40
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
ゼブラフィッシュ Tg(6xTcf/LefBS-miniP:d2EGFP)isi01