論文 - 詳細
| RRC ID | 52502 |
|---|---|
| 著者 | Nagahara H, Seno T, Yamamoto A, Obayashi H, Inoue T, Kida T, Nakabayashi A, Kukida Y, Fujioka K, Fujii W, Murakami K, Kohno M, Kawahito Y. |
| タイトル | Role of allograft inflammatory factor-1 in bleomycin-induced lung fibrosis. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Allograft inflammatory factor-1 (AIF-1) is a protein expressed by macrophages infiltrating the area around the coronary arteries in a rat ectopic cardiac allograft model. We previously reported that AIF-1 is associated with the pathogenesis of rheumatoid arthritis and skin fibrosis in sclerodermatous graft-versus-host disease mice. Here, we used an animal model of bleomycin-induced lung fibrosis to analyze the expression of AIF-1 and examine its function in lung fibrosis. The results showed that AIF-1 was expressed on lung tissues, specifically macrophages, from mice with bleomycin-induced lung fibrosis. Recombinant AIF-1 increased the production of TGF-β which plays crucial roles in the mechanism of fibrosis by mouse macrophage cell line RAW264.7. Recombinant AIF-1 also increased both the proliferation and migration of lung fibroblasts compared with control group. These results suggest that AIF-1 plays an important role in the mechanism underlying lung fibrosis, and may provide an attractive new therapeutic target. |
| 巻・号 | 495(2) |
| ページ | 1901-1907 |
| 公開日 | 2018-1-8 |
| DOI | 10.1016/j.bbrc.2017.12.035 |
| PII | S0006-291X(17)32427-0 |
| PMID | 29225172 |
| MeSH | Animals Bleomycin* Calcium-Binding Proteins / immunology* Cells, Cultured Immunologic Factors / immunology* Macrophage Activation / immunology* Macrophages / immunology* Macrophages / pathology Mice Mice, Inbred C57BL Microfilament Proteins / immunology* Pulmonary Fibrosis / chemically induced* Pulmonary Fibrosis / immunology* Pulmonary Fibrosis / pathology |
| IF | 2.985 |
| 引用数 | 3 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |