| RRC ID |
52523
|
| 著者 |
Ikehata N, Takanashi M, Satomi T, Watanabe M, Hasegawa O, Kono M, Enomoto A, Chikazu D, Kuroda M.
|
| タイトル |
Toll-like receptor 2 activation implicated in oral squamous cell carcinoma development.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
Recent studies have revealed that Toll-like receptors (TLRs) are highly expressed and activated in many types of cancer. Physiologically, TLR2 recognizes bacteria and other microorganisms in the oral cavity; however, the role of TLR2 in oral squamous cell carcinoma (OSCC) is unclear. In this study, we demonstrated that TLR2 is highly expressed in OSCC in comparison with adjacent non-malignant tissue. TLR2 was also expressed in OSCC-derived cell lines, and its expression was activated by ligands derived from bacteria and mycoplasma. Furthermore, to elucidate the mechanism of OSCC progression via TLR2 signal transduction, we focused on microRNAs (miRNAs) that are induced by TLR2 activation. Interestingly, ligand activation of TLR2 induced the expression of miR-146a and we found that downregulation of caspase recruitment domain-containing protein 10 (CARD10) mRNA in OSCC-derived cell lines. Moreover, knockdown of CARD10 induced resistance to cisplatin-induced apoptosis in OSCC cells. These findings suggest that the activation of TLR2 by bacterial components can enhance the progression of OSCC and may be implicated in acquired resistance to cisplatin-induced apoptosis through regulation of the miR-146a pathway.
|
| 巻・号 |
495(3)
|
| ページ |
2227-2234
|
| 公開日 |
2018-1-15
|
| DOI |
10.1016/j.bbrc.2017.12.098
|
| PII |
S0006-291X(17)32492-0
|
| PMID |
29269299
|
| MeSH |
Biomarkers, Tumor / metabolism
Carcinogenesis / metabolism*
Carcinogenesis / pathology*
Carcinoma, Squamous Cell / metabolism*
Carcinoma, Squamous Cell / pathology*
Humans
Mouth Neoplasms / metabolism*
Mouth Neoplasms / pathology*
Toll-Like Receptor 2 / metabolism*
Tumor Cells, Cultured
|
| IF |
2.985
|
| 引用数 |
6
|
| リソース情報 |
| ヒト・動物細胞 |
HSC-3(RCB1975) |
