RRC ID 49221
著者 Wu JK, Tai CY, Feng KL, Chen SL, Chen CC, Chiang AS.
タイトル Long-term memory requires sequential protein synthesis in three subsets of mushroom body output neurons in Drosophila.
ジャーナル Sci Rep
Abstract Creating long-term memory (LTM) requires new protein synthesis to stabilize learning-induced synaptic changes in the brain. In the fruit fly, Drosophila melanogaster, aversive olfactory learning forms several phases of labile memory to associate an odor with coincident punishment in the mushroom body (MB). It remains unclear how the brain consolidates early labile memory into LTM. Here, we survey 183 Gal4 lines containing almost all 21 distinct types of MB output neurons (MBONs) and show that sequential synthesis of learning-induced proteins occurs at three types of MBONs. Downregulation of oo18 RNA-binding proteins (ORBs) in any of these MBONs impaired LTM. And, neurotransmission outputs from these MBONs are all required during LTM retrieval. Together, these results suggest an LTM consolidation model in which transient neural activities of early labile memory in the MB are consolidated into stable LTM at a few postsynaptic MBONs through sequential ORB-regulated local protein synthesis.
巻・号 7(1)
ページ 7112
公開日 2017-8-2
DOI 10.1038/s41598-017-07600-2
PII 10.1038/s41598-017-07600-2
PMID 28769066
PMC PMC5540930
MeSH Animals Drosophila / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism Memory, Long-Term* Neurons / metabolism* Protein Biosynthesis* RNA-Binding Proteins / metabolism
IF 3.998
引用数 12
リソース情報
ショウジョウバエ 10868R-1 10868R-5