RRC ID 50074
著者 Jinnou H, Sawada M, Kawase K, Kaneko N, Herranz-Pérez V, Miyamoto T, Kawaue T, Miyata T, Tabata Y, Akaike T, García-Verdugo JM, Ajioka I, Saitoh S, Sawamoto K.
タイトル Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury.
ジャーナル Cell Stem Cell
Abstract Radial glia (RG) are embryonic neural stem cells (NSCs) that produce neuroblasts and provide fibers that act as a scaffold for neuroblast migration during embryonic development. Although they normally disappear soon after birth, here we found that RG fibers can persist in injured neonatal mouse brains and act as a scaffold for postnatal ventricular-subventricular zone (V-SVZ)-derived neuroblasts that migrate to the lesion site. This injury-induced maintenance of RG fibers has a limited time window during post-natal development and promotes directional saltatory movement of neuroblasts via N-cadherin-mediated cell-cell contacts that promote RhoA activation. Transplanting an N-cadherin-containing scaffold into injured neonatal brains likewise promotes migration and maturation of V-SVZ-derived neuroblasts, leading to functional improvements in impaired gait behaviors. Together these results suggest that RG fibers enable postnatal V-SVZ-derived neuroblasts to migrate toward sites of injury, thereby enhancing neuronal regeneration and functional recovery from neonatal brain injuries.
巻・号 22(1)
ページ 128-137.e9
公開日 2018-1-4
DOI 10.1016/j.stem.2017.11.005
PII S1934-5909(17)30457-5
PMID 29276142
MeSH Animals Animals, Newborn Brain Injuries / pathology* Brain Injuries / physiopathology* Cadherins / metabolism Cell Movement* Lateral Ventricles / pathology Neuroglia / metabolism Neuroglia / pathology* Neuroglia / ultrastructure Neurons / metabolism Neurons / pathology* Neurons / ultrastructure Recovery of Function* rhoA GTP-Binding Protein / metabolism
IF 20.86
引用数 17
リソース情報
遺伝子材料 pENTR4-H1 (RDB04395).