RRC ID 33263
著者 Garg A, Futcher B, Leatherwood J.
タイトル A new transcription factor for mitosis: in Schizosaccharomyces pombe, the RFX transcription factor Sak1 works with forkhead factors to regulate mitotic expression.
ジャーナル Nucleic Acids Res
Abstract Mitotic genes are one of the most strongly oscillating groups of genes in the eukaryotic cell cycle. Understanding the regulation of mitotic gene expression is a key issue in cell cycle control but is poorly understood in most organisms. Here, we find a new mitotic transcription factor, Sak1, in the fission yeast Schizosaccharomyces pombe. Sak1 belongs to the RFX family of transcription factors, which have not previously been connected to cell cycle control. Sak1 binds upstream of mitotic genes in close proximity to Fkh2, a forkhead transcription factor previously implicated in regulation of mitotic genes. We show that Sak1 is the major activator of mitotic gene expression and also confirm the role of Fkh2 as the opposing repressor. Sep1, another forkhead transcription factor, is an activator for a small subset of mitotic genes involved in septation. From yeasts to humans, forkhead transcription factors are involved in mitotic gene expression and it will be interesting to see whether RFX transcription factors may also be involved in other organisms.
巻・号 43(14)
ページ 6874-88
公開日 2015-8-18
DOI 10.1093/nar/gkv274
PII gkv274
PMID 25908789
PMC PMC4538799
MeSH Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism Forkhead Transcription Factors / genetics Forkhead Transcription Factors / metabolism* Gene Deletion Gene Expression Regulation, Fungal* Mitosis / genetics* Repressor Proteins / metabolism Schizosaccharomyces / genetics Schizosaccharomyces / metabolism Schizosaccharomyces pombe Proteins / genetics Schizosaccharomyces pombe Proteins / metabolism* Trans-Activators / metabolism Transcription Factors / genetics Transcription Factors / metabolism*
IF 11.502
引用数 14
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
酵母 FY17283