RRC ID 50315
著者 Molnar C, Estrada B, de Celis JF.
タイトル Tay bridge and extracellular-regulated kinase activity are required for motoneuron function in the Drosophila neural system.
ジャーナル Genes Brain Behav
Abstract Extracellular regulated kinase (Erk) activity is required during neural development for the specification of cell fates in neuroblasts and neuronal lineages, and also regulates several aspects of the activity and survival of mature neurons. The activation of Erk is regulated at multiple levels by kinases and phosphatases that alter its phosphorylation state and by other proteins that regulate its subcellular localization. Here, we find that tay bridge (tay), a negative regulator of Erk in Drosophila imaginal discs, is required in the motoneurons to regulate the number and size of neuromuscular synapses in these cells. The expression of Tay is maximal in motoneurons with low levels of activated ERK, suggesting that Tay modulates the activity of Erk in these cells. We also found that loss of tay expression and increased Erk activity specifically in the motoneurons cause a reversible decrease in walking speed. Impaired motoneurons activity may be caused by alterations in the functionality and number of synaptic boutons developing at the neuromuscular junction in tay mutants.
巻・号 17(8)
ページ e12470
公開日 2018-11-1
DOI 10.1111/gbb.12470
PMID 29524312
MeSH Animals Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila Proteins / physiology* Drosophila melanogaster / genetics MAP Kinase Signaling System / physiology* Motor Neurons / metabolism* Motor Neurons / physiology Neuromuscular Junction / metabolism Neuronal Plasticity / physiology Nuclear Proteins / metabolism Nuclear Proteins / physiology* Phosphorylation Presynaptic Terminals / metabolism Signal Transduction / physiology Synapses / metabolism
IF 3.397
引用数 0
リソース情報
ショウジョウバエ 10079R-2 9375R-1