| RRC ID |
11320
|
| 著者 |
Hashimoto K, Yamano Y, Morishima I.
|
| タイトル |
Induction of tyrosine hydroxylase gene expression by bacteria in the fat body of eri-silkworm, Samia cynthia ricini.
|
| ジャーナル |
Comp Biochem Physiol B Biochem Mol Biol
|
| Abstract |
A cDNA clone encoding tyrosine hydroxylase (TH) was isolated from larval fat body of immunized Samia cynthia ricini. In naive larvae, the TH gene was expressed only in the brain, but strongly induced in fat body and hemocytes after injecting UV-killed bacteria. The induction of the gene was rather short-lived compared to that of antibacterial protein genes, reaching the maximum levels 6h after bacterial challenge, and then quickly diminished. A strong induction of the gene expression was caused by both Gram-negative and positive bacteria and zymosan, but little if any by soluble peptidoglycan or lipopolysaccharide. A possible role of TH in the fat body of bacteria-challenged larvae would be to supply catecholamines as the substrate for phenoloxidase leading to melanization, working together with dopa decarboxylase.
|
| 巻・号 |
149(3)
|
| ページ |
501-6
|
| 公開日 |
2008-3-1
|
| DOI |
10.1016/j.cbpb.2007.11.010
|
| PII |
S1096-4959(07)00440-X
|
| PMID |
18178496
|
| MeSH |
Amino Acid Sequence
Animals
Bacteria / metabolism*
Base Sequence
Bombyx / enzymology*
Bombyx / microbiology*
Cell Wall / metabolism
Clone Cells
DNA, Complementary / isolation & purification
Enzyme Induction
Fat Body / enzymology*
Fat Body / microbiology*
Gene Expression Profiling
Molecular Sequence Data
Organ Specificity
Sequence Alignment
Time Factors
Tyrosine 3-Monooxygenase / biosynthesis*
Tyrosine 3-Monooxygenase / chemistry
Tyrosine 3-Monooxygenase / genetics
|
| IF |
2.219
|
| 引用数 |
8
|
|
WOS 分野
|
ZOOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| カイコ |
NA |
