RRC ID 15370
著者 Wolf MJ, Rockman HA.
タイトル Drosophila, genetic screens, and cardiac function.
ジャーナル Circ Res
Abstract The fruit fly, Drosophila melanogaster, has been used to study genetics, development, and signaling for nearly a century, but only over the past few decades has this tremendous resource been the focus of cardiovascular research. Fly genetics offers sophisticated transgenic systems, molecularly defined genomic deficiencies, genome-wide transgenic RNAi lines, and numerous curated mutants to perform genetic screens. As a genetically tractable model, the fly facilitates gene discovery and can complement mammalian models of disease. The circulatory system in the fly comprises well-defined sets of cardiomyocytes, and methodological advances have permitted accurate characterization of cardiac morphology and function. Thus, fly genetics and genomics offer new approaches for gene discovery of adult cardiac phenotypes to identify evolutionarily conserved molecular signals that drive cardiovascular disease.
巻・号 109(7)
ページ 794-806
公開日 2011-9-16
DOI 10.1161/CIRCRESAHA.111.244897
PII 109/7/794
PMID 21921272
PMC PMC3678974
MeSH Animals Animals, Genetically Modified Cardiovascular Diseases / genetics* Cardiovascular Diseases / metabolism Cardiovascular Diseases / physiopathology Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / embryology Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Gene Expression Regulation, Developmental Genetic Engineering* Genetic Predisposition to Disease Genetic Testing* Humans Morphogenesis / genetics Phenotype
IF 14.467
引用数 32
WOS 分野 CARDIAC & CARDIOVASCULAR SYSTEMS PERIPHERAL VASCULAR DISEASE HEMATOLOGY
リソース情報
情報 http://www.dgrc.kit.ac.jp/en/index.html
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