論文 - 詳細
RRC ID | 47913 |
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著者 | Tokusumi Y, Tokusumi T, Schulz RA. |
タイトル | The nociception genes painless and Piezo are required for the cellular immune response of Drosophila larvae to wasp parasitization. |
ジャーナル | Biochem Biophys Res Commun |
Abstract |
In vertebrates, interaction between the nervous system and immune system is important to protect a challenged host from stress inputs from external sources. In this study, we demonstrate that sensory neurons are involved in the cellular immune response elicited by wasp infestation of Drosophila larvae. Multidendritic class IV neurons sense contacts from external stimuli and induce avoidance behaviors for host defense. Our findings show that inactivation of these sensory neurons impairs the cellular response against wasp parasitization. We also demonstrate that the nociception genes encoding the mechanosensory receptors Painless and Piezo, both expressed in class IV neurons, are essential for the normal cellular immune response to parasite challenge. |
巻・号 | 486(4) |
ページ | 893-897 |
公開日 | 2017-5-13 |
DOI | 10.1016/j.bbrc.2017.03.116 |
PII | S0006-291X(17)30585-5 |
PMID | 28342875 |
MeSH | Animals Drosophila / immunology* Drosophila / parasitology* Drosophila Proteins / immunology* Ion Channels / immunology* Larva / immunology Larva / parasitology Neuroimmunomodulation / immunology Nociceptors / physiology* Wasps / pathogenicity* |
IF | 2.985 |
引用数 | 5 |
WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY BIOPHYSICS |
リソース情報 | |
ショウジョウバエ | 8486R-1 8486R-3 |