RRC ID 18634
著者 Miyata M, Sakaida Y, Matsuzawa H, Yoshinari K, Yamazoe Y.
タイトル Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice.
ジャーナル Biol Pharm Bull
Abstract Human fibroblast growth factor 19 (FGF19) is an enterohepatic hormone that is involved in the regulation of hepatic metabolism of bile acids, lipids, and glucose. Farnesoid X receptor (Fxr)-null mice exhibit steatosis-like symptoms, showing higher hepatic lipid levels than with the wild-type mice. We investigated the influence of FGF19 treatment on hepatic lipogenesis in Fxr-null mice. Recombinant FGF19 treatment (400 µg/kg/d) for 3 d prevented the accumulation of lipid droplets and decreased serum alanine aminotransferase activity and hepatic lipid levels, including those of triglycerides and free fatty acids. The treatment significantly decreased the hepatic mRNA levels of acetyl-CoA carboxylase 1 (Acc1), Cd36, and sterol regulatory element-binding protein-1c (Srebp-1c) as well as those of acetyl-CoA carboxylase 2 (Acc2), stearoyl CoA desaturase 1 (Scd1), and Cyp7a1. FGF19 treatment (4 µg/kg/d) for 3 d also decreased the hepatic free fatty acid levels and mRNA levels of Acc1, Cd36, and Srebp-1c. These results indicate that FGF19-mediated signaling ameliorates disrupted hepatic lipogenesis in Fxr-null mice.
巻・号 34(12)
ページ 1885-9
公開日 2011-1-1
DOI 10.1248/bpb.34.1885
PII JST.JSTAGE/bpb/34.1885
PMID 22130247
MeSH Alanine Transaminase / blood* Alkaline Phosphatase / blood Animals Female Fibroblast Growth Factors / genetics Fibroblast Growth Factors / pharmacology* Gene Expression / drug effects Lipid Metabolism / drug effects* Lipid Metabolism / genetics Liver / drug effects* Liver / metabolism Mice Mice, Knockout RNA, Messenger / metabolism Receptors, Cytoplasmic and Nuclear / deficiency* Receptors, Cytoplasmic and Nuclear / genetics Recombinant Proteins / pharmacology Reverse Transcriptase Polymerase Chain Reaction
IF 1.863
引用数 41
WOS 分野 PHARMACOLOGY & PHARMACY
リソース情報
ヒト・動物細胞 CACO-2(RCB0988)