RRC ID 35788
著者 Li C, Hisamoto N, Matsumoto K.
タイトル Axon Regeneration Is Regulated by Ets-C/EBP Transcription Complexes Generated by Activation of the cAMP/Ca2+ Signaling Pathways.
ジャーナル PLoS Genet
Abstract The ability of specific neurons to regenerate their axons after injury is governed by cell-intrinsic regeneration pathways. In Caenorhabditis elegans, the JNK and p38 MAPK pathways are important for axon regeneration. Axonal injury induces expression of the svh-2 gene encoding a receptor tyrosine kinase, stimulation of which by the SVH-1 growth factor leads to activation of the JNK pathway. Here, we identify ETS-4 and CEBP-1, related to mammalian Ets and C/EBP, respectively, as transcriptional activators of svh-2 expression following axon injury. ETS-4 and CEBP-1 function downstream of the cAMP and Ca2+-p38 MAPK pathways, respectively. We show that PKA-dependent phosphorylation of ETS-4 promotes its complex formation with CEBP-1. Furthermore, activation of both cAMP and Ca2+ signaling is required for activation of svh-2 expression. Thus, the cAMP/Ca2+ signaling pathways cooperatively activate the JNK pathway, which then promotes axon regeneration.
巻・号 11(10)
ページ e1005603
公開日 2015-10-1
DOI 10.1371/journal.pgen.1005603
PII PGENETICS-D-15-01003
PMID 26484536
PMC PMC4618690
MeSH Animals Axons / metabolism* Axons / physiology CCAAT-Enhancer-Binding Proteins / biosynthesis CCAAT-Enhancer-Binding Proteins / genetics* Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans Proteins / biosynthesis Caenorhabditis elegans Proteins / genetics* Calcium Signaling / genetics Cyclic AMP / genetics Cyclic AMP / metabolism Gene Expression Regulation, Developmental Intercellular Signaling Peptides and Proteins / biosynthesis Intercellular Signaling Peptides and Proteins / genetics MAP Kinase Signaling System / genetics Neurons / metabolism Phosphorylation Regeneration / genetics* Signal Transduction / genetics Transcription Factors / biosynthesis Transcription Factors / genetics* p38 Mitogen-Activated Protein Kinases / genetics
IF 5.175
引用数 29
WOS 分野 GENETICS & HEREDITY
リソース情報
線虫 tm2807 tm737