RRC ID |
48000
|
著者 |
Leitão-Gonçalves R, Carvalho-Santos Z, Francisco AP, Fioreze GT, Anjos M, Baltazar C, Elias AP, Itskov PM, Piper MDW, Ribeiro C.
|
タイトル |
Commensal bacteria and essential amino acids control food choice behavior and reproduction.
|
ジャーナル |
PLoS Biol
|
Abstract |
Choosing the right nutrients to consume is essential to health and wellbeing across species. However, the factors that influence these decisions are poorly understood. This is particularly true for dietary proteins, which are important determinants of lifespan and reproduction. We show that in Drosophila melanogaster, essential amino acids (eAAs) and the concerted action of the commensal bacteria Acetobacter pomorum and Lactobacilli are critical modulators of food choice. Using a chemically defined diet, we show that the absence of any single eAA from the diet is sufficient to elicit specific appetites for amino acid (AA)-rich food. Furthermore, commensal bacteria buffer the animal from the lack of dietary eAAs: both increased yeast appetite and decreased reproduction induced by eAA deprivation are rescued by the presence of commensals. Surprisingly, these effects do not seem to be due to changes in AA titers, suggesting that gut bacteria act through a different mechanism to change behavior and reproduction. Thus, eAAs and commensal bacteria are potent modulators of feeding decisions and reproductive output. This demonstrates how the interaction of specific nutrients with the microbiome can shape behavioral decisions and life history traits.
|
巻・号 |
15(4)
|
ページ |
e2000862
|
公開日 |
2017-4-1
|
DOI |
10.1371/journal.pbio.2000862
|
PII |
pbio.2000862
|
PMID |
28441450
|
PMC |
PMC5404834
|
MeSH |
Acetobacter / genetics
Acetobacter / growth & development
Acetobacter / physiology*
Acetobacteraceae / genetics
Acetobacteraceae / growth & development
Acetobacteraceae / physiology
Amino Acids, Essential / administration & dosage
Amino Acids, Essential / analysis
Amino Acids, Essential / deficiency
Amino Acids, Essential / metabolism*
Animals
Animals, Genetically Modified
Appetite Regulation
Behavior, Animal
Complex Mixtures / administration & dosage
Complex Mixtures / chemistry
Drosophila Proteins / antagonists & inhibitors
Drosophila Proteins / genetics
Drosophila Proteins / metabolism
Drosophila melanogaster / genetics
Drosophila melanogaster / microbiology*
Drosophila melanogaster / physiology
Enterococcus faecalis / genetics
Enterococcus faecalis / growth & development
Enterococcus faecalis / physiology
Feeding Behavior*
Female
Food Preferences
Gastrointestinal Microbiome*
Gene Knockout Techniques
Host-Parasite Interactions
Lactobacillus / genetics
Lactobacillus / growth & development
Lactobacillus / physiology*
Oviposition
Species Specificity
Symbiosis*
Yeast, Dried / chemistry
|
IF |
7.076
|
引用数 |
87
|
WOS 分野
|
BIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
ショウジョウバエ |
7399R-3 |