RRC ID 34434
著者 Komura M, Fukuta T, Genda T, Hino S, Aoe S, Kawagishi H, Morita T.
タイトル A short-term ingestion of fructo-oligosaccharides increases immunoglobulin A and mucin concentrations in the rat cecum, but the effects are attenuated with the prolonged ingestion.
ジャーナル Biosci Biotechnol Biochem
Abstract We examined the effects of fructo-oligosaccharides (FOS) on IgA and mucin secretion in the rat cecum after different ingestion periods. Rats were fed a control diet or a diet containing FOS for 1, 2, 4, and 8 wk. FOS ingestion greatly increased IgA and mucin concentrations at 1 and 2 wk, but the effects were disappeared or attenuated at 4 and 8 wk. After 1 wk, FOS induced higher lactobacilli and lactate concentrations and lower cecal pH in the cecum, but the alterations were moderated with the prolonged ingestion accompanying with increasing short-chain fatty acid concentrations. At 1 and 2 wk, FOS increased IgA plasma cells and polymeric immunoglobulin receptor expression in the cecal mucosa and strongly depressed fecal mucinase activities related to the lower cecal pH. These findings may explain the FOS-induced early elevation of IgA and mucin. Clearly, FOS effects on IgA and mucin secretion considerably differ depending on the ingestion period.
巻・号 78(9)
ページ 1592-602
公開日 2014-1-1
DOI 10.1080/09168451.2014.925782
PMID 25209509
MeSH Animals Cecum / enzymology Cecum / metabolism* Diet Eating Fatty Acids, Volatile Feces Humans Immunoglobulin A / biosynthesis* Immunoglobulin A / metabolism Lactic Acid / metabolism Lactobacillus Mucins / biosynthesis* Mucins / metabolism Oligosaccharides / administration & dosage* Polysaccharide-Lyases / metabolism Rats
IF 1.516
引用数 11
WOS 分野 FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
一般微生物 JCM 1190 JCM 1717