RRC ID 52715
著者 Michiue T, Yamamoto T, Yasuoka Y, Goto T, Ikeda T, Nagura K, Nakayama T, Taira M, Kinoshita T.
タイトル High variability of expression profiles of homeologous genes for Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus laevis.
ジャーナル Dev Biol
Abstract Cell signaling pathways, such as Wnt, Hedgehog (Hh), Notch, and Hippo, are essential for embryogenesis, organogenesis, and tissue homeostasis. In this study, we analyzed 415 genes involved in these pathways in the allotetraploid frog, Xenopus laevis. Most genes are retained in two subgenomes called L and S (193 homeologous gene pairs and 29 singletons). This conservation rate of homeologs is much higher than that of all genes in the X. laevis genome (86.9% vs 60.2%). Among singletons, 24 genes are retained in the L subgenome, a rate similar to the average for all genes (82.8% vs 74.6%). In addition, as general components of signal transduction, we also analyzed 32 heparan sulfate proteoglycan (HSPG)-related genes and eight TLE/Groucho transcriptional corepressors-related genes. In these gene sets, all homeologous pairs have been retained. Transcriptome analysis using RNA-seq data from developmental stages and adult tissues demonstrated that most homeologous pairs of signaling components have variable expression patterns, in contrast to the conservative expression profiles of homeologs for transcription factors. Our results indicate that homeologous gene pairs for cell signaling regulation have tended to become subfunctionalized after allotetraploidization. Diversification of signaling pathways by subfunctionalization of homeologs may enhance environmental adaptability. These results provide insights into the evolution of signaling pathways after polyploidization.
巻・号 426(2)
ページ 270-290
公開日 2017-6-15
DOI 10.1016/j.ydbio.2016.12.006
PII S0012-1606(16)30056-2
PMID 28089430
MeSH Animals Frizzled Receptors / biosynthesis Frizzled Receptors / genetics Gene Expression Gene Expression Profiling* Genome Hedgehog Proteins / biosynthesis Hedgehog Proteins / genetics* Molecular Sequence Annotation Receptors, Notch / biosynthesis Receptors, Notch / genetics* Signal Transduction / genetics* Subcellular Fractions / metabolism Synteny Tetraploidy Transcriptome Wnt Proteins / biosynthesis Wnt Proteins / genetics* Wnt Signaling Pathway / genetics Xenopus Proteins / biosynthesis Xenopus Proteins / genetics* Xenopus laevis / genetics*
IF 2.896
引用数 6
リソース情報
ツメガエル・イモリ Xenopus tropicalis