RRC ID 49634
著者 Matuo Y, Izumi Y, Furusawa Y, Shimizu K.
タイトル Biological effects of carbon ion beams with various LETs on budding yeast Saccharomyces cerevisiae.
ジャーナル Mutat Res
Abstract It has been established that irradiation with higher linear energy transfer (LET) increases lethality and mutagenicity more than that with lower LET. However, the characteristics specific to carbon ion beam have not yet been elucidated. Yeast cells were irradiated with carbon ions with an LET of 13 or 50keV/μm, and cell survival and mutation frequency were analyzed. The results, combined with our previous findings for ions with an LET of 107keV/μm, demonstrated that, in conjunction with an increase in LET, cell survival decreased, while mutation frequency increased. This indicates that a carbon ion beam with a higher LET is more mutagenic than one with a lower LET.
巻・号 810
ページ 45-51
公開日 2018-7-1
DOI 10.1016/j.mrfmmm.2017.10.003
PII S0027-5107(17)30052-0
PMID 29146154
MeSH Carbon Cell Survival / radiation effects Dose-Response Relationship, Radiation Heavy Ion Radiotherapy* Heavy Ions Linear Energy Transfer* Mutagenesis / radiation effects* Mutation Rate* Saccharomyces cerevisiae / radiation effects*
IF 2.463
引用数 4
リソース情報
酵母 BY19656 BY19654