| RRC ID |
35675
|
| 著者 |
Kikuchi Y, Hosono K, Yamashita J, Kawabata Y, Okubo K.
|
| タイトル |
Glucocorticoid receptor exhibits sexually dimorphic expression in the medaka brain.
|
| ジャーナル |
Gen Comp Endocrinol
|
| Abstract |
The differential impact of stress on brain functions of males and females has been widely observed in vertebrates. Recent evidence suggests that stress-induced glucocorticoid signaling affects sexual differentiation and sex changes in teleost fish. These facts led us to postulate that there were sex differences in glucocorticoid signaling in the teleost brain that underlie some sex differences in their physiological and behavioral traits. Here we found sexually dimorphic expression of a glucocorticoid receptor gene (gr1) in the brain of medaka fish (Oryzias latipes), with females having greater expression in several preoptic and thalamic nuclei. Further, gr1 exhibits female-biased expression in neurons of the anterior parvocellular preoptic nucleus that produce the neuropeptides vasotocin and gonadotropin-releasing hormone 1 (these neuropeptides have been implicated in the regulation of neuroendocrine and behavioral functions). These findings suggest that glucocorticoids have a greater influence on physiology and behavior mediated by these neuropeptides in females than in males, which may contribute to sex differences in the brain's response to stress.
|
| 巻・号 |
223
|
| ページ |
47-53
|
| 公開日 |
2015-11-1
|
| DOI |
10.1016/j.ygcen.2015.09.031
|
| PII |
S0016-6480(15)00275-0
|
| PMID |
26433060
|
| MeSH |
Animals
Brain / metabolism*
Female
In Situ Hybridization
Male
Neurons / cytology
Neurons / metabolism*
Neuropeptides / metabolism*
Oryzias / genetics
Oryzias / growth & development
Oryzias / metabolism*
RNA, Messenger / genetics
Real-Time Polymerase Chain Reaction
Receptors, Glucocorticoid / genetics*
Receptors, Glucocorticoid / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Sex Factors
|
| IF |
2.428
|
| 引用数 |
7
|
|
WOS 分野
|
ENDOCRINOLOGY & METABOLISM
|
| リソース情報 |
| メダカ |
cDNA
d-rR/TOKYO (MT837) |
