RRC ID 4100
著者 Kurosaka H, Takano-Yamamoto T, Yamashiro T, Agata K.
タイトル Comparison of molecular and cellular events during lower jaw regeneration of newt (Cynops pyrrhogaster) and West African clawed frog (Xenopus tropicalis).
ジャーナル Dev Dyn
Abstract When mammals, including humans, lose a major part of their lower jaw, they are unable to regenerate the lost structures. Urodele amphibians, especially newts, can regenerate their lower jaw after amputation, whereas most anuran amphibians, including the West African clawed frog, can not. In the present study, we investigated the difference between newts and frogs during lower jaw regeneration. One difference was the distribution of myosin heavy chain (MHC) mRNA after lower jaw amputation: MHC mRNA was immediately expressed at the tip of the amputated lower jaw in newts but not in frogs. Moreover, there were proliferating cells that expressed Pax7 in newts but not in frogs, although proliferating cells were present in both animals. These results suggest that the difference of the jaw-regenerating abilities between newts and frogs depends on the expression of MHC mRNA at the tip of the amputated jaw and the contribution of Pax7-positive cells.
巻・号 237(2)
ページ 354-65
公開日 2008-2-1
DOI 10.1002/dvdy.21419
PMID 18161063
MeSH Animals Bone Regeneration / physiology* Bromodeoxyuridine DNA Primers / genetics Gene Expression Profiling Immunohistochemistry In Situ Hybridization Mandible / diagnostic imaging Mandible / physiology* Myosin Heavy Chains / metabolism* PAX7 Transcription Factor / metabolism RNA, Messenger / metabolism* Reverse Transcriptase Polymerase Chain Reaction Salamandridae / physiology* Species Specificity Tomography, X-Ray Computed Xenopus / physiology*
IF 3.275
引用数 24
WOS 分野 ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY
リソース情報
ツメガエル・イモリ