RRC ID 46577
著者 Chen L, Zhou S.
タイトル "CRASH"ing with the worm: insights into L1CAM functions and mechanisms.
ジャーナル Dev Dyn
Abstract The L1 family of cell adhesion molecules (L1CAMs) in vertebrates has long been studied for its roles in nervous system development and function. Members of this family have been associated with distinct neurological disorders that include CRASH, autism, 3p syndrome, and schizophrenia. The conservation of L1CAMs in Drosophila and Caenorhabditis elegans allows the opportunity to take advantage of these simple model organisms and their accessible genetic manipulations to dissect L1CAM functions and mechanisms of action. This review summarizes the discoveries of L1CAMs made in C. elegans, showcasing this simple model organism as a powerful system to uncover L1CAM mechanisms and roles in healthy and diseased states.
巻・号 239(5)
ページ 1490-501
公開日 2010-5-1
DOI 10.1002/dvdy.22269
PMID 20225255
PMC PMC3428060
MeSH Animals Caenorhabditis elegans Nervous System / growth & development Nervous System Diseases Neural Cell Adhesion Molecule L1 / physiology*
IF 3.275
引用数 17
WOS 分野 ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY
リソース情報
線虫 tm3056