RRC ID 6334
著者 Pujol-Martí J, Baudoin JP, Faucherre A, Kawakami K, López-Schier H.
タイトル Progressive neurogenesis defines lateralis somatotopy.
ジャーナル Dev Dyn
Abstract Fishes and amphibians localize hydromechanical variations along their bodies using the lateral-line sensory system. This is possible because the spatial distribution of neuromasts is represented in the hindbrain by a somatotopic organization of the lateralis afferent neurons' central projections. The mechanisms that establish lateralis somatotopy are not known. Using BAPTI and neuronal tracing in the zebrafish, we demonstrate growth anisotropy of the posterior lateralis ganglion. We characterized a new transgenic line for in vivo imaging to show that although peripheral growth-cone structure adumbrates somatotopy, the order of neurogenesis represents a more accurate predictor of the position of a neuron's central axon along the somatotopic axis in the hindbrain. We conclude that progressive neurogenesis defines lateralis somatotopy.
巻・号 239(7)
ページ 1919-30
公開日 2010-7-1
DOI 10.1002/dvdy.22320
PMID 20549716
MeSH Animals Animals, Genetically Modified Ganglia, Sensory / cytology Ganglia, Sensory / metabolism Neurogenesis / genetics Neurogenesis / physiology* Sensory Receptor Cells / cytology Sensory Receptor Cells / metabolism Zebrafish / embryology* Zebrafish / genetics
IF 3.275
引用数 19
WOS 分野 ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY
リソース情報
ゼブラフィッシュ rw0130a(Tg (Huc:Kaede)) HGn39D(HGn39D) hspGFF53A UAS:EGFP