論文 - 詳細
RRC ID | 6334 |
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著者 | Pujol-Martí J, Baudoin JP, Faucherre A, Kawakami K, López-Schier H. |
タイトル | Progressive neurogenesis defines lateralis somatotopy. |
ジャーナル | Dev Dyn |
Abstract |
Fishes and amphibians localize hydromechanical variations along their bodies using the lateral-line sensory system. This is possible because the spatial distribution of neuromasts is represented in the hindbrain by a somatotopic organization of the lateralis afferent neurons' central projections. The mechanisms that establish lateralis somatotopy are not known. Using BAPTI and neuronal tracing in the zebrafish, we demonstrate growth anisotropy of the posterior lateralis ganglion. We characterized a new transgenic line for in vivo imaging to show that although peripheral growth-cone structure adumbrates somatotopy, the order of neurogenesis represents a more accurate predictor of the position of a neuron's central axon along the somatotopic axis in the hindbrain. We conclude that progressive neurogenesis defines lateralis somatotopy. |
巻・号 | 239(7) |
ページ | 1919-30 |
公開日 | 2010-7-1 |
DOI | 10.1002/dvdy.22320 |
PMID | 20549716 |
MeSH | Animals Animals, Genetically Modified Ganglia, Sensory / cytology Ganglia, Sensory / metabolism Neurogenesis / genetics Neurogenesis / physiology* Sensory Receptor Cells / cytology Sensory Receptor Cells / metabolism Zebrafish / embryology* Zebrafish / genetics |
IF | 3.275 |
引用数 | 19 |
WOS 分野 | ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY |
リソース情報 | |
ゼブラフィッシュ | rw0130a(Tg (Huc:Kaede)) HGn39D(HGn39D) hspGFF53A UAS:EGFP |