RRC ID 51537
著者 Martínez-Velázquez LA, Ringstad N.
タイトル Antagonistic regulation of trafficking to Caenorhabditis elegans sensory cilia by a Retinal Degeneration 3 homolog and retromer.
ジャーナル Proc Natl Acad Sci U S A
Abstract Sensory neurons often possess cilia with elaborate membrane structures that are adapted to the sensory modality of the host cell. Mechanisms that target sensory transduction proteins to these specialized membrane domains remain poorly understood. Here, we show that a homolog of the human retinal dystrophy gene Retinal Degeneration 3 (RD3) is a Golgi-associated protein required for efficient trafficking of a sensory receptor, the receptor-type guanylate cyclase GCY-9, to cilia in chemosensory neurons of the nematode Caenorhabditis elegans The trafficking defect caused by mutation of the nematode RD3 homolog is suppressed in vivo by mutation of key components of the retromer complex, which mediates recycling of cargo from endosomes to the Golgi. Our data show that there exists a critical balance in sensory neurons between the rates of anterograde and retrograde trafficking of cargo destined for the sensory cilium and this balance requires molecular specialization at an early stage of the secretory pathway.
巻・号 115(3)
ページ E438-E447
公開日 2018-1-16
DOI 10.1073/pnas.1712302115
PII 1712302115
PMID 29282322
PMC PMC5776970
MeSH Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cilia / physiology* Eye Proteins / classification Eye Proteins / genetics Eye Proteins / metabolism* Gene Expression Regulation Protein Transport / physiology* Sensory Receptor Cells / physiology
IF 9.412
引用数 4
リソース情報
線虫 tm1320 tm2121 tm2124 tm2159 tm2991 tm2999 tm544 tm659 tm847