RRC ID 34466
著者 Kasakura K, Takahashi K, Itoh T, Hosono A, Momose Y, Itoh K, Nishiyama C, Kaminogawa S.
タイトル Commensal bacteria directly suppress in vitro degranulation of mast cells in a MyD88-independent manner.
ジャーナル Biosci Biotechnol Biochem
Abstract The intestine harbors a substantial number of commensal bacteria that provide considerable benefits to the host. Epidemiologic studies have identified associations between alterations in the composition of the intestinal microbiota and the development of allergic disease. However, the cellular and molecular mechanisms underlying these effects remain to be determined. Here, we show that heat-killed commensal bacteria suppressed degranulation of mast cells in vitro in a MyD88-independent manner. In particular, Enterococcus faecalis showed the strongest suppression of degranulation through partial inhibition of Ca(2+) signaling upon the high affinity IgE receptor (FcεRI) cross-linking.
巻・号 78(10)
ページ 1669-76
公開日 2014-1-1
DOI 10.1080/09168451.2014.930327
PMID 25273132
MeSH Animals Cell Degranulation* Enterococcus faecalis / physiology* Female Intracellular Space / metabolism Mast Cells / cytology* Mice Myeloid Differentiation Factor 88 / metabolism* Signal Transduction
IF 1.516
引用数 11
WOS 分野 FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
一般微生物 JCM 1649 JCM 5824 JCM 5826 JCM 5827