RRC ID 47913
著者 Tokusumi Y, Tokusumi T, Schulz RA.
タイトル The nociception genes painless and Piezo are required for the cellular immune response of Drosophila larvae to wasp parasitization.
ジャーナル Biochem Biophys Res Commun
Abstract In vertebrates, interaction between the nervous system and immune system is important to protect a challenged host from stress inputs from external sources. In this study, we demonstrate that sensory neurons are involved in the cellular immune response elicited by wasp infestation of Drosophila larvae. Multidendritic class IV neurons sense contacts from external stimuli and induce avoidance behaviors for host defense. Our findings show that inactivation of these sensory neurons impairs the cellular response against wasp parasitization. We also demonstrate that the nociception genes encoding the mechanosensory receptors Painless and Piezo, both expressed in class IV neurons, are essential for the normal cellular immune response to parasite challenge.
巻・号 486(4)
ページ 893-897
公開日 2017-5-13
DOI 10.1016/j.bbrc.2017.03.116
PII S0006-291X(17)30585-5
PMID 28342875
MeSH Animals Drosophila / immunology* Drosophila / parasitology* Drosophila Proteins / immunology* Ion Channels / immunology* Larva / immunology Larva / parasitology Neuroimmunomodulation / immunology Nociceptors / physiology* Wasps / pathogenicity*
IF 2.985
引用数 5
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY BIOPHYSICS
リソース情報
ショウジョウバエ 8486R-1 8486R-3