RRC ID 32434
著者 Kohsaka H, Takasu E, Morimoto T, Nose A.
タイトル A group of segmental premotor interneurons regulates the speed of axial locomotion in Drosophila larvae.
ジャーナル Curr Biol
Abstract BACKGROUND:Animals control the speed of motion to meet behavioral demands. Yet, the underlying neuronal mechanisms remain poorly understood. Here we show that a class of segmentally arrayed local interneurons (period-positive median segmental interneurons, or PMSIs) regulates the speed of peristaltic locomotion in Drosophila larvae.
RESULTS:PMSIs formed glutamatergic synapses on motor neurons and, when optogenetically activated, inhibited motor activity, indicating that they are inhibitory premotor interneurons. Calcium imaging showed that PMSIs are rhythmically active during peristalsis with a short time delay in relation to motor neurons. Optogenetic silencing of these neurons elongated the duration of motor bursting and greatly reduced the speed of larval locomotion.
CONCLUSIONS:Our results suggest that PMSIs control the speed of axial locomotion by limiting, via inhibition, the duration of motor outputs in each segment. Similar mechanisms are found in the regulation of mammalian limb locomotion, suggesting that common strategies may be used to control the speed of animal movements in a diversity of species.
巻・号 24(22)
ページ 2632-42
公開日 2014-11-17
DOI 10.1016/j.cub.2014.09.026
PII S0960-9822(14)01147-6
PMID 25438948
MeSH Action Potentials Animals Behavior, Animal / physiology Drosophila / cytology Drosophila / physiology* Larva / cytology Larva / physiology Locomotion / physiology* Motor Neurons / physiology*
IF 9.601
引用数 41
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
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