RRC ID 36236
著者 Ge W, Deng Q, Guo T, Hong X, Kugler JM, Yang X, Cohen SM.
タイトル Regulation of pattern formation and gene amplification during Drosophila oogenesis by the miR-318 microRNA.
ジャーナル Genetics
Abstract Pattern formation during epithelial development requires the coordination of multiple signaling pathways. Here, we investigate the functions of an ovary-enriched miRNA, miR-318, in epithelial development during Drosophila oogenesis. mir-318 maternal loss-of-function mutants were female-sterile and laid eggs with abnormal morphology. Removal of mir-318 disrupted the dorsal-anterior follicle cell patterning, resulting in abnormal dorsal appendages. mir-318 mutant females also produced thin and fragile eggshells due to impaired chorion gene amplification. We provide evidence that the ecdysone signaling pathway activates expression of miR-318 and that miR-318 cooperates with Tramtrack69 to control the switch from endocycling to chorion gene amplification during differentiation of the follicular epithelium. The multiple functions of miR-318 in oogenesis illustrate the importance of miRNAs in maintaining cell fate and in promoting the developmental transition in the female follicular epithelium.
巻・号 200(1)
ページ 255-65
公開日 2015-5-1
DOI 10.1534/genetics.115.174748
PII genetics.115.174748
PMID 25786856
PMC PMC4423367
MeSH Animals Body Patterning* Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / embryology Drosophila melanogaster / genetics* Drosophila melanogaster / metabolism Female Gene Amplification* Gene Expression Regulation, Developmental MicroRNAs / genetics* Mutation Oogenesis* Repressor Proteins / genetics Repressor Proteins / metabolism Signal Transduction
IF 4.015
引用数 10
WOS 分野 GENETICS & HEREDITY
リソース情報
ショウジョウバエ DGRC#206424