RRC ID 49595
著者 Miwa A, Sawada Y, Tamaoki D, Yokota Hirai M, Kimura M, Sato K, Nishiuchi T.
タイトル Nicotinamide mononucleotide and related metabolites induce disease resistance against fungal phytopathogens in Arabidopsis and barley.
ジャーナル Sci Rep
Abstract Nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD), is known to act as a functional molecule in animals, whereas its function in plants is largely unknown. In this study, we found that NMN accumulated in barley cultivars resistant to phytopathogenic fungal Fusarium species. Although NMN does not possess antifungal activity, pretreatment with NMN and related metabolites enhanced disease resistance to Fusarium graminearum in Arabidopsis leaves and flowers and in barley spikes. The NMN-induced Fusarium resistance was accompanied by activation of the salicylic acid-mediated signalling pathway and repression of the jasmonic acid/ethylene-dependent signalling pathways in Arabidopsis. Since NMN-induced disease resistance was also observed in the SA-deficient sid2 mutant, an SA-independent signalling pathway also regulated the enhanced resistance induced by NMN. Compared with NMN, NAD and NADP, nicotinamide pretreatment had minor effects on resistance to F. graminearum. Constitutive expression of the NMNAT gene, which encodes a rate-limiting enzyme for NAD biosynthesis, resulted in enhanced disease resistance in Arabidopsis. Thus, modifying the content of NAD-related metabolites can be used to optimize the defence signalling pathways activated in response to F. graminearum and facilitates the control of disease injury and mycotoxin accumulation in plants.
巻・号 7(1)
ページ 6389
公開日 2017-7-25
DOI 10.1038/s41598-017-06048-8
PII 10.1038/s41598-017-06048-8
PMID 28743869
PMC PMC5526872
MeSH Arabidopsis / genetics Arabidopsis / microbiology* Disease Resistance* Flowers / microbiology Fusarium / drug effects Hordeum / genetics Hordeum / microbiology* NAD / metabolism NAD / pharmacology Nicotinamide Mononucleotide / chemistry Nicotinamide Mononucleotide / metabolism* Nicotinamide Mononucleotide / pharmacology Nicotinamide-Nucleotide Adenylyltransferase / genetics Plant Diseases / prevention & control Plant Leaves / microbiology Plant Proteins / genetics Salicylic Acid / metabolism Signal Transduction
IF 3.998
引用数 5
リソース情報
オオムギ Barley Strain H.E.S.4