RRC ID 47785
著者 Barlan K, Cetera M, Horne-Badovinac S.
タイトル Fat2 and Lar Define a Basally Localized Planar Signaling System Controlling Collective Cell Migration.
ジャーナル Dev Cell
Abstract Collective migration of epithelial cells underlies diverse tissue-remodeling events, but the mechanisms that coordinate individual cell migratory behaviors for collective movement are largely unknown. Studying the Drosophila follicular epithelium, we show that the cadherin Fat2 and the receptor tyrosine phosphatase Lar function in a planar signaling system that coordinates leading and trailing edge dynamics between neighboring cells. Fat2 signals from each cell's trailing edge to induce leading edge protrusions in the cell behind, in part by stabilizing Lar's localization in these cells. Conversely, Lar signals from each cell's leading edge to stimulate trailing edge retraction in the cell ahead. Fat2/Lar signaling is similar to planar cell polarity signaling in terms of sub-cellular protein localization; however, Fat2/Lar signaling mediates short-range communication between neighboring cells instead of transmitting long-range information across a tissue. This work defines a key mechanism promoting epithelial migration and establishes a different paradigm for planar cell-cell signaling.
巻・号 40(5)
ページ 467-477.e5
公開日 2017-3-13
DOI 10.1016/j.devcel.2017.02.003
PII S1534-5807(17)30072-2
PMID 28292425
PMC PMC5354100
MeSH Animals Cadherins / chemistry Cadherins / metabolism* Cell Membrane / metabolism Cell Movement* Cell Polarity* Drosophila Proteins / chemistry Drosophila Proteins / metabolism* Drosophila melanogaster / cytology* Drosophila melanogaster / metabolism* Epithelial Cells / cytology Epithelial Cells / metabolism Female Ovarian Follicle / cytology Protein Domains Protein Stability Pseudopodia / metabolism Receptor-Like Protein Tyrosine Phosphatases / metabolism* Signal Transduction*
IF 10.092
引用数 31
WOS 分野 DEVELOPMENTAL BIOLOGY CELL BIOLOGY
リソース情報
ショウジョウバエ 9749R-3