| RRC ID |
5601
|
| 著者 |
Okamoto H, Sato T, Aizawa H.
|
| タイトル |
Transgenic technology for visualization and manipulation of the neural circuits controlling behavior in zebrafish.
|
| ジャーナル |
Dev Growth Differ
|
| Abstract |
The vertebrate brain is innately equipped with neural circuits that make quick behavioral decisions possible. Elucidating these neural circuits, determining how their master plans are encoded in the genome, and revealing how they can be modified by postnatal experiences will facilitate our understanding of how nature and nurture interact to establish an animal's behavior. In this review, we explain how transgenic zebrafish can cast insights into the developmental mechanisms and functional roles of the neural circuits that directly and indirectly control visuomotor behavior, by taking as an example a transgenic line Tg(brn3a-hsp70:GFP) enabling visualization of the tectobulbar and habenulo-interpeduncular tracts. These insights emphasize the benefits of applying advanced transgenic technology in zebrafish to future research into this area.
|
| 巻・号 |
50 Suppl 1
|
| ページ |
S167-75
|
| 公開日 |
2008-6-1
|
| DOI |
10.1111/j.1440-169X.2008.01003.x
|
| PII |
DGD1003
|
| PMID |
18430169
|
| MeSH |
Animals
Animals, Genetically Modified
Behavior, Animal
Developmental Biology / methods*
Gene Expression Regulation, Developmental
Genetic Techniques
Green Fluorescent Proteins / metabolism
Models, Biological
Models, Genetic
Models, Neurological
Neurons / metabolism*
Transgenes*
Vision, Ocular
Zebrafish
|
| IF |
1.723
|
| 引用数 |
10
|
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ゼブラフィッシュ |
Review |
