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RRC ID 1584
著者 Matsuura K, Wada H, Nagai T, Iijima Y, Minamino T, Sano M, Akazawa H, Molkentin JD, Kasanuki H, Komuro I.
タイトル Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle.
ジャーナル J Cell Biol
Abstract The concept of the plasticity or transdifferentiation of adult stem cells has been challenged by the phenomenon of cell fusion. In this work, we examined whether neonatal cardiomyocytes fuse with various somatic cells including endothelial cells, cardiac fibroblasts, bone marrow cells, and endothelial progenitor cells spontaneously in vitro. When cardiomyocytes were cocultured with endothelial cells or cardiac fibroblasts, they fused and showed phenotypes of cardiomyocytes. Furthermore, cardiomyocytes reentered the G2-M phase in the cell cycle after fusing with proliferative noncardiomyocytes. Transplanted endothelial cells or skeletal muscle-derived cells fused with adult cardiomyocytes in vivo. In the cryoinjured heart, there were Ki67-positive cells that expressed both cardiac and endothelial lineage marker proteins. These results suggest that cardiomyocytes fuse with other cells and enter the cell cycle by maintaining their phenotypes.
巻・号 167(2)
ページ 351-63
公開日 2004-10-25
DOI 10.1083/jcb.200312111
PII jcb.200312111
PMID 15492039
PMC PMC2172538
MeSH Adenoviridae / genetics Animals Animals, Genetically Modified Cell Communication Cell Cycle Cell Differentiation Cell Division Cell Lineage Cell Proliferation Cell Transplantation Cells, Cultured Endothelium, Vascular / cytology Endothelium, Vascular / metabolism Fibroblasts / metabolism G2 Phase Green Fluorescent Proteins / metabolism Immunohistochemistry Ki-67 Antigen / biosynthesis Lac Operon Male Mice Models, Genetic Muscle, Skeletal / cytology Myocytes, Cardiac / metabolism* Nocodazole / pharmacology Phenotype Rats Rats, Wistar Recombination, Genetic Time Factors Transgenes
IF 8.811
引用数 93
WOS 分野 CELL BIOLOGY
リソース情報
遺伝子材料 AxCANCre (RDB01748)