論文 - 詳細
| RRC ID | 1902 |
|---|---|
| 著者 | Jin C, Kato K, Chimura T, Yamasaki T, Nakade K, Murata T, Li H, Pan J, Zhao M, Sun K, Chiu R, Ito T, Nagata K, Horikoshi M, Yokoyama KK. |
| タイトル | Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2. |
| ジャーナル | Nat Struct Mol Biol |
| Abstract |
Jun dimerization protein-2 (JDP2) is a component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Here, we examine the functional mechanisms of JDP2 and show that it can inhibit p300-mediated acetylation of core histones in vitro and in vivo. Inhibition of histone acetylation requires the N-terminal 35 residues and the DNA-binding region of JDP2. In addition, we demonstrate that JDP2 has histone-chaperone activity in vitro. These results suggest that the sequence-specific DNA-binding protein JDP2 may control transcription via direct regulation of the modification of histones and the assembly of chromatin. |
| 巻・号 | 13(4) |
| ページ | 331-8 |
| 公開日 | 2006-4-1 |
| DOI | 10.1038/nsmb1063 |
| PII | nsmb1063 |
| PMID | 16518400 |
| MeSH | Acetylation Animals Base Sequence Cell Cycle Proteins / antagonists & inhibitors Cell Cycle Proteins / metabolism DNA / genetics DNA / metabolism HeLa Cells Histone Acetyltransferases / antagonists & inhibitors Histone Acetyltransferases / metabolism Histones / metabolism* Humans In Vitro Techniques Mice Molecular Chaperones / chemistry Molecular Chaperones / genetics Molecular Chaperones / metabolism Nucleosomes / metabolism Protein Binding Protein Structure, Tertiary Recombinant Proteins / chemistry Recombinant Proteins / genetics Recombinant Proteins / metabolism Repressor Proteins / chemistry Repressor Proteins / genetics Repressor Proteins / metabolism* Sequence Deletion Transcription Factors / antagonists & inhibitors Transcription Factors / metabolism p300-CBP Transcription Factors |
| IF | 11.98 |
| 引用数 | 55 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 遺伝子材料 | pcDNA4-mmJDP2_wt (RDB04755) pGST-mmJDP2_full (RDB04757). |